Dr. Kevin Cromar was in Washington DC on December 12, 2018 to provide a public statement on EPA's Integrated Science Assessment (ISA) for Particulate Matter. His comments were made during the Chartered Clean Air Scientific Advisory Committee (CASAC) Public Meeting to peer-review the ISA document. Cromar focused on the appropriate role of causal inference statistical approaches in observation studies. He supported the weight-of-evidence approach used in the ISA to determine causal associations between particulate matter air pollution and the health endpoints contained in the ISA. In Cromar's estimation, the ISA document is a good representation of the scientific evidence concerning health effects of particle pollution.