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Ambient PM2.5 Exposure

and Risk of Lung Cancer Incidence in North America and Europe

+ Marya Ghazipura, Eric Garshick, Kevin Cromar

Abstract

Regulatory analysis in the US has not previously identified lung cancer incidence as an adverse health outcome of fine particle air pollution (PM2.5). In an effort to provide the latest scientific knowledge in support of the pending scientific evaluation of PM2.5 by the US Environmental Protection Agency (EPA), a systematic review and meta-analysis was conducted to examine the relationship between long-term PM2.5 exposure and lung cancer incidence. We extracted data from four studies based on North American study populations and two studies based on European study populations in accordance with PRISMA guidelines. The results of the meta-analysis indicate a 25% increased risk of lung cancer incidence per 10 μg m−3 increase in PM2.5 concentrations (RR = 1.25, 95% CI: 1.12–1.40), which is higher than previously published risks for lung cancer mortality. These effects were observed at concentrations relevant to current US standards. It is recommended that the EPA identifies lung cancer incidence, in addition to previous evidence for lung cancer mortality, as an adverse effect of long-term PM2.5 exposures.

 

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Marya Ghazipura is a Doctoral Researcher for the Air Quality Program.

Eric Garshick, MD is an Adjunct Associate Professor at the Boston University School of Medicine.

Kevin Cromar, Ph.D., is a program director at the Marron Institute of Urban Management and an Associate Professor of Environmental Medicine and Population Health at New York University Grossman School of Medicine.

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